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Some studies have shown that the efficacy of tamoxifen, as measured by the risk of breast cancer relapse mortality, may be reduced when co-prescribed with paroxetine as a result of paroxetine s irreversible inhibition of cyp2d6 see drug interactions .

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Concurrent treatment with a cyp2d6 inhibitor such as bupropion, fluoxetine, or paroxetine has been shown to increase plasma atomoxetine by 100 or more, as well as increase n -desmethylatomoxetine levels and decrease plasma 4-hydroxyatomoxetine levels by a similar degree.

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